The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Cytokine responses during mucosal infections: role in disease pathogenesis and host defence

På svenska

Author

Summary, in English

Mucosal pathogens use diverse and highly specific molecular mechanisms to activate mucosal inflammation. It may even be argued that their virulence depends on the inflammatory response that they induce. Some bacteria target epithelial cells and trigger them to produce inflammatory mediators but others cross the mucosa and activate macrophages or dendritic cells. Although systemic release of inflammatory mediators causes many symptoms and signs of infection, local chemokine production leads to the recruitment of inflammatory cells and lymphocytes that participate directly in the clearance of bacteria from mucosal sites. In this way, mucosal inflammation is a two-edged sword responsible for disease associated tissue destruction and crucial for the antimicrobial defence. Understanding of these pathways should create tools to enhance the defence and interfere with disease.

Publishing year

1999

Language

English

Pages

99-103

Publication/Series

Current Opinion in Microbiology

Volume

2

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Immunology in the medical area
  • Microbiology in the medical area

Status

Published

ISBN/ISSN/Other

  • ISSN: 1879-0364