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Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD

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Author

  • Nadine Hovelmeyer
  • F Thomas Wunderlich
  • Ramin Massoumi
  • Charlotte G Jakobsen
  • Jian Song
  • Marcus A Worns
  • Carsten Merkwirth
  • Andrew Kovalenko
  • Monique Aumailley
  • Dennis Strand
  • Jens C Bruning
  • Peter R Galle
  • David Wallach
  • Reinhard Fässler
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Summary, in English

B cell homeostasis is regulated by multiple signaling processes, including nuclear factor-kappaB (NF-kappaB), BAFF-, and B cell receptor signaling. Conditional disruption of genes involved in these pathways has shed light on the mechanisms governing signaling from the cell surface to the nucleus. We describe a novel mouse strain that expresses solely and excessively a naturally occurring splice variant of CYLD (CYLD(ex7/8) mice), which is a deubiquitinating enzyme that is integral to NF-kappaB signaling. This shorter CYLD protein lacks the TRAF2 and NEMO binding sites present in full-length CYLD. A dramatic expansion of mature B lymphocyte populations in all peripheral lymphoid organs occurs in this strain. The B lymphocytes themselves exhibit prolonged survival and manifest a variety of signaling disarrangements that do not occur in mice with a complete deletion of CYLD. Although both the full-length and the mutant CYLD are able to interact with Bcl-3, a predominant nuclear accumulation of Bcl-3 occurs in the CYLD mutant B cells. More dramatic, however, is the accumulation of the NF-kappaB proteins p100 and RelB in CYLD(ex7/8) B cells, which, presumably in combination with nuclear Bcl-3, results in increased levels of Bcl-2 expression. These findings suggest that CYLD can both positively and negatively regulate signal transduction and homeostasis of B cells in vivo, depending on the expression of CYLD splice variants.

Publishing year

2007

Language

English

Pages

2615-2627

Publication/Series

Journal of Experimental Medicine

Volume

204

Issue

11

Document type

Journal article

Publisher

Rockefeller University Press

Topic

  • Cancer and Oncology

Status

Published

Research group

  • Cell Pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 1540-9538