Transient hypertriglyceridemia of infancy

Summary, in English

A premature boy who had suffered from IRDS, bronchopulmonary dysplasia and retinopathy of prematurity developed massive hypertriglyceridemia (48.1 mmol/L) together with moderate hypercholesterolemia (12.6 mmol/L) at 5 months of age. Lipoprotein electrophoresis revealed a marked elevation of the level of the very low density lipoprotein fraction. There was a moderate decrease in the activity of a lipolytic enzyme, lipoprotein lipase (LPL). The child had neither liver or renal disorder nor any inflammatory disease. The hyperlipidemia disappeared spontaneously at the age of 3 years. The cause of the decreased LPL activity could not be established. A partial genetic deficiency in lipoprotein lipase appears the most likely explanation, since no signs of secondary lowering of LPL activity could be found.

• Author: A Nilsson; E Ortqvist; H Lagercrantz; Peter Nilsson-Ehle; J I Henter
• Department/s: Division of Clinical Chemistry and Pharmacology
• Publishing year: 1996
• Language: English
• Pages: 1508-1510
• Publication/Series: Acta Pædiatrica
• Volume: 85
• Issue: 12
• Links: http://dx.doi.org/10.1111/j.1651-2227.1996.tb13964.x
• Document type: Journal article
• Publisher: Wiley-Blackwell
• Topic: Pediatrics
• Keywords: Hypertriglyceridemia; infancy; lipoprotein lipase
• Status: Published
• ISBN/ISSN/Other: ISSN: 1651-2227