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Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties.

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Author

  • Jessica Nilsson
  • Albert A Shteinman
  • Eva Degerman
  • Eva A Enyedy
  • Tamás Kiss
  • Ulrich Behrens
  • Dieter Rehder
  • Ebbe Nordlander

Summary, in English

Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H(2)papy) with VOSO(4) in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)}(2) μ-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H(2)glysal) with VOSO(4) gives [(glysal)VO(H(2)O)] (2) and reaction of salicylamide (Hsalam) with VOSO(4) in methanol gives [(salam)(2)VO] (3). The crystal structure of the oxido-bridged complex 1 is reported. The insulin-mimetic activity of all three complexes was evaluated with respect to their ability to phosphorylate protein kinase B (PKB). The speciations of complexes 1 and 2 were studied over the pH range 2-10. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect.

Publishing year

2011

Language

English

Pages

1795-1800

Publication/Series

Journal of Inorganic Biochemistry

Volume

105

Document type

Journal article

Publisher

Elsevier

Topic

  • Biochemistry and Molecular Biology

Status

Published

Research group

  • Insulin Signal Transduction

ISBN/ISSN/Other

  • ISSN: 1873-3344