The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly (vinyl alcohol) gel

På svenska

Author

Summary, in English

Copolymers of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with N,N-dimethylarcrylamide (DMAA) formed insoluble interpolymer complexes with mucin from porcine stomach at pH 9.0. The complex formation based on boronate-sugar interactions took place between the similarly charged macromolecules and resulted in coacervate particles formation, which depended both on pH and ionic strength of the solution. the coacervation rate displayed a maximum at the intermediate DMAA_NAAPBA copolymer: mucin weight ratio, that is a pattern typical of interpolymer complex formation.

Department/s

  • Biotechnology
  • Department of Food Technology, Engineering and Nutrition

Publishing year

2008

Language

English

Pages

36-43

Publication/Series

International Journal of Pharmaceutics

Volume

358

Issue

1-2

Document type

Journal article

Publisher

Elsevier

Topic

  • Industrial Biotechnology
  • Food Engineering

Keywords

  • Mucoadhesive
  • Drug delivery
  • Boronic acid
  • Controlled release
  • Smart material

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-3476