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Prion-like transmission of protein aggregates in neurodegenerative diseases.

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Author

  • Patrik Brundin
  • Ronald Melki
  • Ron Kopito

Summary, in English

Neurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates. Recent studies suggest that these aggregates are capable of crossing cellular membranes and can directly contribute to the propagation of neurodegenerative disease pathogenesis. We propose that, once initiated, neuropathological changes might spread in a 'prion-like' manner and that disease progression is associated with the intercellular transfer of pathogenic proteins. The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies.

Publishing year

2010

Language

English

Pages

301-307

Publication/Series

Nature Reviews. Molecular Cell Biology

Volume

11

Issue

4

Document type

Journal article review

Publisher

Nature Publishing Group

Topic

  • Neurosciences

Status

Published

ISBN/ISSN/Other

  • ISSN: 1471-0072