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Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity

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Author

Summary, in English

The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.

Publishing year

2011

Language

English

Pages

290-293

Publication/Series

Molecular Nutrition and Food Research

Volume

55

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Nutrition and Dietetics

Keywords

  • Adipose tissue
  • Alkylresorcinols
  • Lipolysis
  • Type 2 diabetes
  • Whole
  • grain

Status

Published

Project

  • ANTIDIABETIC FOOD CENTRE

Research group

  • Molecular Endocrinology
  • Insulin Signal Transduction

ISBN/ISSN/Other

  • ISSN: 1613-4133