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In vitro activity of synthetic antimicrobial peptides against Candida

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Author

  • Wojciech Kamysz
  • Piotr Nadolski
  • Anna Kedzia
  • Oscar Cirioni
  • Francesco Barchiesi
  • Andrea Giacometti
  • Giorgio Scalise
  • Jerzy Lukasiak
  • Marcin Okroj

Summary, in English

Yeast-like fungi are the most common cause of fungal infections in humans. Actually, in the age of opportunistic infections and increasing resistance, development of modern antifungal agents becomes a very important challenge. This paper describes synthesis and antimicrobial assay of four naturally occurring peptide antibiotics (aurein 1.2, citropin 1.1, temporin A, uperin 3.6) and three chemically engineered analogues actually passing clinical trials (iseganan, pexiganan, omiganan) against Candida strains isolated from patients with infections of the oral cavity or respiratory tract. The peptides were synthesized using solid-phase method and purified by high-performance liquid chromatography. Biological tests were performed using the broth microdilution method. The antifungal activity of the peptide antibiotics was compared to that of nystatin and amphotericin B. We found synthetic peptides to be generally less potent than amphotericin B or nystatin. However, some of the naturally occurring peptides still retained reasonable antifungal activities which were higher than these of iseganan, pexiganan or omiganan. We think that the naturally occurring peptide antibiotics included in our study can be a good matrix for development of novel antifungal compounds.

Publishing year

2006

Language

English

Pages

303-307

Publication/Series

Polish Journal of Microbiology

Volume

55

Issue

4

Document type

Journal article

Publisher

Polskie Towarzystwo Mikrobiologów

Topic

  • Medicinal Chemistry

Status

Published

Research group

  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1733-1331