Pathogenic Mechanisms in Lupus Nephritis: Nucleosomes Bind Aberrant Laminin β1 With High Affinity and Colocalize in the Electron-Dense Deposits.

Summary, in English

Apoptotic nucleosomes are structurally and immunologically involved in lupus nephritis. The purpose of this study was to examine the expression and function of laminins and their interactions with nucleosomes in the kidneys of patients with lupus nephritis, using surface plasmon resonance (SPR) analysis.

• Author: Anders Olin; Matthias Mörgelin; Lennart Truedsson; Gunnar Sturfelt; Anders Bengtsson
• Department/s: Infection Medicine (BMC); Division of Microbiology, Immunology and Glycobiology - MIG; Rheumatology; EpiHealth: Epidemiology for Health
• Publishing year: 2014
• Language: English
• Pages: 397-406
• Publication/Series: Arthritis & Rheumatology
• Volume: 66
• Issue: 2
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24504812?dopt=Abstract; http://dx.doi.org/10.1002/art.38250
• Document type: Journal article
• Publisher: John Wiley & Sons Inc.
• Topic: Rheumatology and Autoimmunity
• Status: Published
• ISBN/ISSN/Other: ISSN: 2326-5205