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Effect of antisense peptide binding on the dimerization of human cystatin C - gel electrophoresis and molecular modeling studies

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Author

  • K Stachowiak
  • S Rodziewicz-Motowidlo
  • R Sosnowska
  • F Kasprzykowski
  • L Lankiewicz
  • Anders Grubb
  • Z Grzonka

Summary, in English

Human cystatin C (HCC) shows a tendency to dimerize. This process is particularly easy in the case of the L68Q HCC mutant and might lead to formation of amyloid deposits in brain arteries of young adults. Our purpose was to find ligands of monomeric HCC that can prevent its dimerization. Eleven antisense peptide ligands of monomeric HCC were designed and synthesized. The influence of these ligands on HCC dimerization was studied using gel electrophoresis and molecular modeling methods. The results suggest that all the designed peptides interact with monomeric HCC facilitating its dimerization rather than preventing it.

Publishing year

2004

Language

English

Pages

153-160

Publication/Series

Acta Biochimica Polonica

Volume

51

Issue

1

Document type

Journal article

Publisher

Panstwowe Wydawnictwo Naukowe

Topic

  • Medicinal Chemistry
  • Pharmacology and Toxicology

Keywords

  • dimerization
  • human cystatin C
  • antisense peptides
  • molecular dynamics

Status

Published

ISBN/ISSN/Other

  • ISSN: 0001-527X