Phomol, a new antiinflammatory metabolite from an endophyte of the medicinal plant Erythrina crista-galli
Author
Summary, in English
Phomol (1), a novel antibiotic, was isolated from fermentations of a Phomopsis species in the course of a screening of endophytic fungi from the medicinal plant Erythrina crista-galli. For this Argentinean leguminosa anti inflammatory and neuroleptic activities have been described. The compound exhibits antifungal, antibacterial and weak cytotoxic acticity. The anti inflammatory activity was tested in different reporter gene assays (TNF-alpha, STAT1/STAT2 and NF-kappaB) and in an ear edema model in mice. In the reporter gene assays I exhibited no activity, whereas I showed interesting antiinflammatory activity in the mouse ear assay. The compound is a polyketide lactone and its structure was elucidated by spectroscopic methods.
Department/s
Publishing year
2004
Language
English
Pages
559-563
Publication/Series
Journal of Antibiotics
Volume
57
Issue
9
Links
Document type
Journal article
Publisher
Japan Antibiotics Research Association
Topic
- Organic Chemistry
Status
Published
ISBN/ISSN/Other
- ISSN: 0021-8820