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Enzymatic synthesis of dipeptide units of the D-D-configuration in aqueous media

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Author

Summary, in English

The enzymatic synthesis of dipeptide units of the d-d-configuration in aqueous media, catalysed by muramoyl-pentapeptide carboxypeptidase (E.C.3.4.17.8), is described. Ac-l-Lys(Ac)-d-Ala-d-Lac-OH and Ac-d-Ala-OMe were used as acyl-components. Neutral, basic, and hydrophobic amino acids acting as nucleophiles were incorporated. The enzyme is stereospecific in that only the d-enantiomers of amino acids or amino acid derivatives were incorporated. As nucleophiles, the unmodified amino acids resulted in higher product yields compared with using the corresponding amino acid derivatives. Product yields ranged from 40 to 87%

Publishing year

1990

Language

English

Pages

147-152

Publication/Series

International Journal of Peptide and Protein Research

Volume

35

Issue

2

Document type

Journal article

Publisher

Munksgaard Forlag

Topic

  • Biochemistry and Molecular Biology

Status

Published

Research group

  • Nanomedicine and Biomaterials

ISBN/ISSN/Other

  • ISSN: 0367-8377