Expression of functional toll like receptor 4 in estrogen receptor/progesterone receptor-negative breast cancer.

Summary, in English

Toll-like receptors (TLRs) are a family of pattern recognition receptors that are expressed on cells of the innate immune system. The ligands can be pathogen derived (pathogen associated molecular patterns; PAMPs) or endogenous (damage associated molecular patters; DAMPs) that when bound induces activation of nuclear factor kappa B (NF-κB) and transcription of pro-inflammatory genes. TLRs have also been discovered in various malignant cell types, but with unknown function.

• Author: Meliha Mehmeti; Roni Allaoui; Caroline Bergenfelz; Lao Saal; Stephen P Ethier; Martin Johansson; Karin Jirström; Karin Leandersson
• Department/s: Cancer Immunology, Malmö; Experimental Infection Medicine, Malmö; Breastcancer-genetics; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Clinical pathology, Malmö; Tumor microenvironment
• Publishing year: 2015
• Language: English
• Publication/Series: Breast Cancer Research
• Volume: 17
• Issue: 1
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26392082?dopt=Abstract; http://dx.doi.org/10.1186/s13058-015-0640-x
• Document type: Journal article
• Publisher: BioMed Central (BMC)
• Topic: Cancer and Oncology
• Status: Published
• Research group: Cancer Immunology, Malmö; Experimental Infection Medicine, Malmö; Clinical pathology, Malmö
• ISBN/ISSN/Other: ISSN: 1465-5411