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Comparison of three methods to find the vapor activity of a hydration step

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Author

Summary, in English

The formation of a stochiometric salt hydrate takes place at a well defined vapor activity. We have compared three methods to measure this vapor activity. In two of the methods we used a sorption balance in step mode and in ramp mode, respectively, and in one method we used a newly developed sorption microcalorimeter. The tests were made with the formation of morphine sulphate pentahydrate from its dihydrate at 25°C. With all three methods this transition was found to take place at a vapor activity close to 0.21.

Publishing year

2001

Language

English

Pages

77-81

Publication/Series

European Journal of Pharmaceutics and Biopharmaceutics

Volume

51

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Materials Engineering

Status

Published

ISBN/ISSN/Other

  • ISSN: 0939-6411