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3,4-dideoxyglucosone-3-ene in peritoneal dialysis fluids infused into the peritoneal cavity cannot be found in plasma.

På svenska

Author

  • Martin Erixon
  • Anders Wieslander
  • Torbjörn Lindén
  • Ola Carlsson
  • Jan Åke Jönsson
  • Ole Simonsen
  • Per Kjellstrand

Summary, in English

OBJECTIVE: Glucose degradation products (GDPs) are important for the outcome of peritoneal dialysis (PD) treatment. The most cytotoxic GDP found in conventionally manufactured fluids, 3,4-dideoxyglucosone-3-ene (3,4-DGE), may in addition be recruited from 3-deoxyglucosone (3-DG). What happens with the GDPs in the fluid infused into patients during PD is not known. We investigated whether 3,4-DGE and 3-DG in PD fluid can be found in plasma during treatment. DESIGN: Patients on PD were dialyzed with a conventional PD fluid containing 43 micromol/L 3,4-DGE and 281 micromol/L 3-DG. Parallel experiments were performed in rats and in vitro with human plasma. The rats were dialyzed with a PD fluid containing 100 micromol/L 3,4-DGE and 200 micromol/L 3-DG. RESULTS: The 3,4-DGE concentration in the peritoneum declined at a much higher rate during the dwell than did the 3-DG concentration. However, 3,4-DGE was not detected in the plasma of patients or of rats during dialysis. The 3-DG concentration in plasma peaked shortly after infusion of fluid into the peritoneal cavity. The 3,4-DGE concentration during experimental incubation in plasma declined rapidly; the 3-DG concentration declined only 10% as rapidly (or less). CONCLUSION: During dialysis, 3,4-DGE could not be detected in plasma of either PD patients or rats, presumably because of its high reactivity. On the other hand, 3-DG may pass through the membrane and be detected in the blood.

Publishing year

2009

Language

English

Pages

28-31

Publication/Series

Peritoneal Dialysis International

Volume

29 Suppl 2

Document type

Journal article

Publisher

Multimed Inc.

Topic

  • Urology and Nephrology

Keywords

  • Peritoneal dialysis fluid
  • glucose degradation products
  • 3
  • 3-DG
  • 4-DGE
  • plasma
  • advanced glycation end-products

Conference name

12th Congress of the International-Society-for-Peritoneal-Dialysis

Conference date

2008-06-20 - 2008-06-24

Status

Published

ISBN/ISSN/Other

  • ISSN: 1718-4304