A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects
Author
Summary, in English
Objective: Reduced serum adiponectin levels have been found in obesity and type 2 diabetes and variations in the adiponectin gene (APM1) have been associated with type 2 diabetes and features of the metabolic syndrome in different populations. Study Design: Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.5 +/- 4.9 kg/m(2)) nondiabetic subjects. Results: APM1 mRNA expression in visceral fat was correlated with serum adiponectin levels (r=0.54, P=0.012). In visceral, but not in subcutaneous, adipose tissue APM1 mRNA level was 38% higher among carriers of the APM1 G276T T allele (G/T and T/T) than among carriers of the G/G genotype (0.91 +/- 0.06 for G/T and T/T carriers vs 0.66 +/- 0.09 for G/G carriers, P=0.013). Carriers of the T allele also had significantly higher body fat percent compared to G/G carriers (65 +/- 6 vs 56 +/- 10%, P=0.011). Conclusion: Our results indicate that genetic variation in APM1 influences the expression of the gene in visceral adipose tissue and suggest a potential role for such variation in regulation of body fat accumulation in obese subjects.
Publishing year
2006
Language
English
Pages
226-232
Publication/Series
International Journal of Obesity
Volume
30
Issue
2
Links
Document type
Journal article
Publisher
Nature Publishing Group
Topic
- Nutrition and Dietetics
Keywords
- adiponectin
- APM1
- gene expression
- adipose tissue
Status
Published
Research group
- Genomics, Diabetes and Endocrinology
ISBN/ISSN/Other
- ISSN: 1476-5497