Stochastic aspects of transmitter release and bioenergetic dysfunction in isolated nerve terminals
Author
Summary, in English
Synaptosomes (isolated nerve terminals) have been studied for more than 40 years. The preparation allows aspects of transmitter metabolism and release to be studied ex vivo from specific brain regions of animals of any age. Conditions can be devised to enable the terminals to fire spontaneous action potentials, allowing the presynaptic control of glutamate exocytosis to be studied. Recent developments have greatly increased the sensitivity with which the bioenergetics of the intra-synaptosomal mitochondria can be investigated.
Department/s
Publishing year
2010
Language
English
Pages
457-459
Publication/Series
Biochemical Society Transactions
Volume
38
Document type
Conference paper
Publisher
Portland Press
Topic
- Biochemistry and Molecular Biology
Keywords
- exocytosis
- brain
- potassium channel
- glutamate
- synaptosome
Conference name
Conference on Synaptopathies - Dysfunction of Synaptic Function
Conference date
2009-09-02 - 2009-09-04
Status
Published
ISBN/ISSN/Other
- ISSN: 0300-5127
- ISSN: 1470-8752