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Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population

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Author

  • E. Shyong Tai
  • Xue Ling Sim
  • Twee Hee Ong
  • Tien Yin Wong
  • Seang Mei Saw
  • Tin Aung
  • Sekar Kathiresan
  • Marju Orho-Melander
  • Jose M. Ordovas
  • Jonathan T. Tan
  • Mark Seielstad
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Summary, in English

We conducted a cross-sectional study of Malay articipants aged 40-80 years (n = 2,932) to examine the associations between polymorphisms at newly identified, lipid-associated loci with blood lipid levels and prevalent cardiovascular disease (CVD) in a Malay population in Asia. A polymorphism adjacent to the TRIB1 locus (rs17321515) was associated with elevated total cholesterol and LDL-cholesterol (LDL-C) after adjustment for age and sex (both P values <0.007) and with increased risk of coronary heart disease and CVD [odds ratio (OR) 1.23, 95% confidence interval (95% CI) 1.03-1.46; and OR 1.2, 95% CI 1.02-1.42, respectively] under an additive model of inheritance. In addition, using recessive models of inheritance, polymorphisms on chromosome 19 adjacent to the CILP2 and PBX4 loci (rs16996148) and on chromosome 1 at the GALNT2 locus (rs4846914) were associated with elevated HDL-C (P = 0.005) and lower LDL-C (P = 0.048), respectively. Although novel, the former is consistent with the association between this polymorphism and lower blood triglycerides observed in the initial studies conducted in populations of European ancestry. Neither showed statistically significant association with CVD. These observations should form the basis of further investigation to identify the causative polymorphisms at this locus, and also to understand the mechanistic roles that this protein may play in lipoprotein metabolism in Asians and other populations.-Tai, E. S., X. L. Sim, T. H. Ong, T. Y. Wong, S. M. Saw, T. Aung, S. Kathiresan, M. Orho-Melander, J. M. Ordovas, J. T. Tan, and M. Seielstad. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. J. Lipid Res. 2009. 50: 514-520.

Publishing year

2009

Language

English

Pages

514-520

Publication/Series

Journal of Lipid Research

Volume

50

Issue

3

Document type

Journal article

Publisher

American Society for Biochemistry and Molecular Biology

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • genetics
  • ethnic group
  • coronary heart disease

Status

Published

ISBN/ISSN/Other

  • ISSN: 1539-7262