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Polyphenolic Constituents and Antioxidant Potential of Geranium stepporum Davis

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Author

  • Didem Sohretoglu
  • Mahmut Koray Sakar
  • Suna Atasayar Sabuncuoglu
  • Hilal Ozgunes
  • Olov Sterner

Summary, in English

The crude MeOH extract prepared from the aerial parts of G. stepporum and its EtOAc, n-BuOH, H2O subextracts were screened for their inhibitory activity on H2O2-induced lipid peroxidation in human red blood cells. The EtOAc subextract was found to be the most active one and its chemical composition was further analysed. Six polyphenolic secondary metabolites including quercetin (1), rutin (2), methyl gallate (3), pusilagin (4), 1,3,6-tri-O-galloyl-beta-glucospyranose (5) and 1,2,3,4,6-penta-O-galloyl-beta-glucopyranose (6) were isolated from the EtOAc extract by successive chromatographic methods (Sephadex CC, silica gel CC and P-TLC). The structures of the isolates were elucidated by 1D- and 2D-NMR and MS. This is the first report of occurrence of hydrolysable tannins in G. stepporum.

Publishing year

2011

Language

English

Pages

22-28

Publication/Series

Records of Natural Products

Volume

5

Issue

1

Document type

Journal article

Publisher

ACG Publications

Topic

  • Organic Chemistry

Keywords

  • Geranium stepporum
  • Geraniaceae
  • galloylglucopyranose
  • hydrolysable
  • tannin
  • flavonoid
  • antioxidant effect

Status

Published

ISBN/ISSN/Other

  • ISSN: 1307-6167