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Neurocan is dispensable for brain development

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Author

  • Xiao-Hong Zhou
  • Cord Brakebusch
  • Henry Matthies
  • Toshitaka Oohashi
  • Emilio Hirsch
  • Markus Moser
  • Manfred Krug
  • Constanze I. Seidenbecher
  • Tobias M. Boeckers
  • Uwe Rauch
  • Reinhard Buettner
  • Eckart D. Gundelfinger
  • Reinhard Fässler
Show all

Summary, in English

Neurocan is a component of the extracellular matrix in brain. Due to its inhibition of neuronal adhesion and outgrowth in vitro and its expression pattern in vivo it was suggested to play an important role in axon guidance and neurite growth. To study the role of neurocan in brain development we generated neurocan-deficient mice by targeted disruption of the neurocan gene. These mice are viable and fertile and have no obvious deficits in reproduction and general performance. Brain anatomy, morphology, and ultrastructure are similar to those of wild-type mice. Perineuronal nets surrounding neurons appear largely normal. Mild deficits in synaptic plasticity may exist, as maintenance of late-phase hippocampal long-term potentiation is reduced. These data indicate that neurocan has either a redundant or a more subtle function in the development of the brain.

Publishing year

2001

Language

English

Pages

5970-5978

Publication/Series

Molecular and Cellular Biology

Volume

21

Issue

17

Document type

Journal article

Publisher

American Society for Microbiology

Topic

  • Cell and Molecular Biology

Status

Published

Research group

  • Vessel Wall Biology

ISBN/ISSN/Other

  • ISSN: 0270-7306