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Oxytocin receptor mimetics prepared by molecular imprinting.

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Author

Summary, in English

Oxytocin receptor mimetics were prepared by molecular imprinting using Z-oxytocin as the template. Comparative binding studies with reference polymers showed that the imprinted polymers recognized both Z-oxytocin and unprotected oxytocin selectively. The dissociation constants were 47 µM and 102 µM,respectively, and the density of binding sites was 12 µmol/g. The synthetic oxytocin receptors were easily prepared, possessed high mechanical and chemical stability, and were reused without loss of selectivity and capacity after regeneration by extraction.

Publishing year

2000

Language

English

Pages

27-33

Publication/Series

Letters in Peptide Science

Volume

7

Issue

1

Document type

Journal article

Publisher

Springer

Topic

  • Organic Chemistry

Status

Published

Research group

  • Nanomedicine and Biomaterials

ISBN/ISSN/Other

  • ISSN: 0929-5666