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Fibrocytes and the tissue niche in lung repair

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Author

Summary, in English

Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers related to leukocytes, hematopoietic stem cells and a diverse set of fibroblast phenotypes. Fibrocytes can be recruited from the circulation to the tissue where they further can differentiate and proliferate into various mesenchymal cell types depending on the tissue niche. This local tissue niche is important because it modulates the fibrocytes and coordinates their role in tissue behaviour and repair. However, plasticity of a niche may be co-opted in chronic airway diseases such as asthma, idiopathic pulmonary fibrosis and obliterative bronchiolitis. This review will therefore focus on a possible role of fibrocytes in pathological tissue repair processes in those diseases.

Publishing year

2011

Language

English

Publication/Series

Respiratory Research

Volume

12

Document type

Journal article review

Publisher

BioMed Central (BMC)

Topic

  • Respiratory Medicine and Allergy

Status

Published

Research group

  • Lung Biology

ISBN/ISSN/Other

  • ISSN: 1465-9921