Protein kinase C modulation of the ethanol effect on serotonin2 receptor transduction in astrocytes

Summary, in English

Acute ethanol exposure stimulated serotonin2 receptor signalling in cultured astrocytes. Pretreatment with the protein kinase C inhibitor H7 significantly increased the ethanol-induced potentiation of [3H]-inositol phosphates accumulation. The increase could be explained by an augmented activation of phospholipase C. The results indicate a role of PKC for the modulation of ethanol effects on cellular signalling.

• Author: Per Simonsson; Elisabeth Hansson; Christer Alling
• Department/s: Clinical Chemistry, Malmö; Division of Clinical Chemistry and Pharmacology
• Publishing year: 1989
• Language: English
• Pages: 401-404
• Publication/Series: Alcohol and Alcoholism
• Volume: 24
• Issue: 5
• Links: http://alcalc.oxfordjournals.org/cgi/reprint/24/5/401
• Document type: Journal article
• Publisher: Oxford University Press
• Topic: Substance Abuse
• Status: Published
• Research group: Clinical Chemistry, Malmö
• ISBN/ISSN/Other: ISSN: 1464-3502