Complex karyotypic anomalies in a bizarre leiomyoma of the uterus.

Summary, in English

Cytogenetic investigation of short-term cultures from a bizarre leiomyoma of the uterus, a tumor type not hitherto karyotypically characterized, revealed two abnormal clones with multiple complex rearrangements. Three-fourths of the aberrant cells were hypodiploid with the composite karyotype 38-44, XX,-6,-7,-10,-11,+20,-22, r(1), der(2) (:2p23cen2q13::1q211qter), der(2)t(2;9)(p21;q13), t(5;?)(q35;?), t(5;?),(q35;?), + der(5)t(5;15)(q11;q15), der(8)t(8;11)(q24;q13), t(15;?)(p12;?), der(16)t(12;16)(q13;p13),+r,+mar. The remaining abnormal mitoses were hypotetraploid, with chromosome numbers ranging from 74 to 86. These massively rearranged cells showed the same markers that were found in the hypodiploid clone, but in duplicate, indicating that this clone had arisen through polyploidization of hypodiploid cells. Flow cytometry revealed a DNA index of 1.03.

• Author: Mef Nilbert; Sverre Heim; Nils Mandahl; Ulla-Maria Flodérus; Helena Willén; Bo Baldetorp; Felix Mitelman
• Department/s: Breastcancer-genetics; Division of Clinical Genetics
• Publishing year: 1989
• Language: English
• Pages: 131-134
• Publication/Series: Genes, Chromosomes and Cancer
• Volume: 1
• Issue: 2
• Links: http://dx.doi.org/10.1002/gcc.2870010204
• Document type: Journal article
• Publisher: John Wiley & Sons Inc.
• Topic: Cancer and Oncology; Medical Genetics
• Status: Published
• ISBN/ISSN/Other: ISSN: 1045-2257