Intranasal Immunization of Mice with Group B Streptococcal Protein Rib and Cholera Toxin B Subunit Confers Protection against Lethal Infection.

Summary, in English

Intranasal immunization of mice with Rib, a cell surface protein of group B streptococcus (GBS), conjugated to or simply coadministered with the recombinant cholera toxin B subunit, induces systemic immunoglobulin G (IgG) and local IgA antibody responses and confers protection against lethal GBS infection. These findings have implications for the development of a human GBS vaccine.

• Author: Charlotte U Larsson; Jan Holmgren; Gunnar Lindahl; Charlotta Bergquist
• Department/s: Division of Medical Microbiology
• Publishing year: 2004
• Language: English
• Pages: 1184-1187
• Publication/Series: Infection and Immunity
• Volume: 72
• Issue: 2
• Full text: - 61 kB; Download statistics
• Links: http://dx.doi.org/10.1128/IAI.72.2.1184-1187.2004
• Document type: Journal article
• Publisher: American Society for Microbiology
• Topic: Microbiology in the medical area
• Status: Published
• ISBN/ISSN/Other: ISSN: 1098-5522