A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

Summary, in English

Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.

• Author: Caroline Brorsson; Regine Bergholdt; Marketa Sjögren; Stefanie Eising; Karina Meden Sorensen; David M. Hougaard; Marju Orho-Melander; Leif Groop; Flemming Pociot
• Department/s: Translational Muscle Research
• Publishing year: 2008
• Language: English
• Pages: 386-388
• Publication/Series: Molecular Genetics and Metabolism
• Volume: 94
• Issue: 3
• Links: http://dx.doi.org/10.1016/j.ymgme.2008.02.011
• Document type: Journal article
• Publisher: Elsevier
• Topic: Endocrinology and Diabetes
• Keywords: beta-cell function; genetics; type 1 diabetes; SLC30A8; zinc transporter
• Status: Published
• Research group: Genomics, Diabetes and Endocrinology
• ISBN/ISSN/Other: ISSN: 1096-7192