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Immune complexes, rheumatoid factors, and cellular immunological parameters in patients with giant cell arteritis

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Author

Summary, in English

Circulating immune complexes were found in 2 of 15 patients with giant cell arteritis (GCA) by using a solid phase Clq enzyme linked immunoabsorbent assay (ELISA). The prevalence in controls was 5%. Rheumatoid factor could be demonstrated in 2 out of 27 patients and in 11% of the controls by using a similar ELISA technique. The prevalence of T cells in blood was similar in 25 patients with GCA and in controls. The blood lymphocyte blastogenic response to the mitogens, phytohaemagglutinin, concanavalin-A, and pokeweed mitogen did not differ in 25 untreated patients compared with controls. Stimulation of lymphocytes by arterial homogenates was tested in 8 patients. In no case could a significant simulation by obtained. We conclude that immune complexes and rheumatoid factors are present in the same low frequency in GCA patients as in the normal population, and that the studied parameters of cellular immunity appear to be normal.

Publishing year

1981

Language

English

Pages

276-280

Publication/Series

Annals of the Rheumatic Diseases

Volume

40

Issue

3

Document type

Journal article

Publisher

BMJ Publishing Group

Topic

  • Rheumatology and Autoimmunity

Status

Published

ISBN/ISSN/Other

  • ISSN: 1468-2060