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Enteric neuropathy can be induced by high fat diet in vivo and palmitic Acid exposure in vitro.

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Author

Summary, in English

Obese and/or diabetic patients have elevated levels of free fatty acids and increased susceptibility to gastrointestinal symptoms. Since the enteric nervous system is pivotal in regulating gastrointestinal functions alterations or neuropathy in the enteric neurons are suspected to occur in these conditions. Lipid induced intestinal changes, in particular on enteric neurons, were investigated in vitro and in vivo using primary cell culture and a high fat diet (HFD) mouse model.

Department/s

Publishing year

2013

Language

English

Publication/Series

PLoS ONE

Volume

8

Issue

12

Document type

Journal article

Publisher

Public Library of Science (PLoS)

Topic

  • Cardiac and Cardiovascular Systems
  • Gastroenterology and Hepatology

Status

Published

Research group

  • Neurogastroenterology

ISBN/ISSN/Other

  • ISSN: 1932-6203