Influence of twenty potentially antiviral substances on in vitro multiplication of hepatitis A virus
Author
Summary, in English
A multiwell tissue culture system was developed to study the influence of various substances on hepatitis A virus (HAV) propagation. A panel of 20 substances of different structure types, each with known effect against at least some viruses, was studied at a concentration of 100 microM. Three substances showed reproducible inhibition. The strongest inhibitor, arabinosylcytosine, also produced cytotoxic changes in cells down to a concentration of 1 microM, and its effect was considered as nonspecific. Amantadine and ribavirin showed a moderate effect at 100 microM. A stronger inhibition was seen at 250 and 500 microM, doses that are toxic and impractical for clinical use. Although no promising candidates for antiviral treatment of hepatitis A have emerged from the present study, the assay model described here would seem useful in the screening of substances with inhibitory effects on HAV.
Department/s
Publishing year
1986
Language
English
Pages
103-112
Publication/Series
Antiviral Research
Volume
6
Issue
2
Document type
Journal article
Publisher
Elsevier
Topic
- Microbiology in the medical area
Keywords
- ribavirin
- amantadine
- arabinosylcytosine
- hepatitis A
Status
Published
Research group
- Clinical Microbiology, Malmö
ISBN/ISSN/Other
- ISSN: 0166-3542