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Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo.

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Author

  • Derek K Chu
  • Rodrigo Jimenez-Saiz
  • Christopher P Verschoor
  • Tina D Walker
  • Susanna Goncharova
  • Alba Llop-Guevara
  • Pamela Shen
  • Melissa E Gordon
  • Nicole G Barra
  • Jennifer D Bassett
  • Joshua Kong
  • Ramzi Fattouh
  • Kathy D McCoy
  • Dawn M Bowdish
  • Jonas Erjefält
  • Oliver Pabst
  • Alison A Humbles
  • Roland Kolbeck
  • Susan Waserman
  • Manel Jordana
Show all

Summary, in English

Eosinophils natively inhabit the small intestine, but a functional role for them there has remained elusive. Here, we show that eosinophil-deficient mice were protected from induction of Th2-mediated peanut food allergy and anaphylaxis, and Th2 priming was restored by reconstitution with il4(+/+) or il4(-/-) eosinophils. Eosinophils controlled CD103(+) dendritic cell (DC) activation and migration from the intestine to draining lymph nodes, events necessary for Th2 priming. Eosinophil activation in vitro and in vivo led to degranulation of eosinophil peroxidase, a granule protein whose enzymatic activity promoted DC activation in mice and humans in vitro, and intestinal and extraintestinal mouse DC activation and mobilization to lymph nodes in vivo. Further, eosinophil peroxidase enhanced responses to ovalbumin seen after immunization. Thus, eosinophils can be critical contributors to the intestinal immune system, and granule-mediated shaping of DC responses can promote both intestinal and extraintestinal adaptive immunity.

Publishing year

2014

Language

English

Pages

1657-1672

Publication/Series

Journal of Experimental Medicine

Volume

211

Issue

8

Document type

Journal article

Publisher

Rockefeller University Press

Topic

  • Immunology in the medical area

Status

Published

Research group

  • Airway Inflammation and Immunology

ISBN/ISSN/Other

  • ISSN: 1540-9538