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Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.

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Author

Summary, in English

In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 mu M. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.

Publishing year

2006

Language

English

Pages

495-499

Publication/Series

Journal of Antibiotics

Volume

59

Issue

8

Document type

Journal article

Publisher

Japan Antibiotics Research Association

Topic

  • Organic Chemistry

Keywords

  • cylindrocarpon
  • cytotoxic
  • new metabolite
  • cyclopeptide

Status

Published

ISBN/ISSN/Other

  • ISSN: 0021-8820