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Separation of amino acids, peptides and proteins on molecularly imprinted stationary phases.

Author

Summary, in English

Stationary phases, to be used in high-performance liquid chromatography, were tailor-made for the separation of amino acids, peptides and proteins. The stationary phases were prepared by molecular imprinting, applying two different approaches. Low-molecular-mass compounds were imprinted in bulk polymers by copolymerization of functional monomers and cross-linkers in the presence of the compound of interest, the print molecule. These polymers were, after extraction of the print molecule, successfully applied as chiral stationary phases, showing high resolution and load capacity. The development of a surface-imprinting approach for the preparation of stationary phases selective for proteins is also discussed.

Publishing year

1995

Language

English

Pages

317-323

Publication/Series

Journal of Chromatography A

Volume

691

Issue

1-2

Document type

Journal article

Publisher

Elsevier

Topic

  • Biochemistry and Molecular Biology

Status

Published

Research group

  • Nanomedicine and Biomaterials

ISBN/ISSN/Other

  • ISSN: 0021-9673