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T3N0 glottic carcinoma: DNA S-phase as a predictor of the outcome after radiotherapy

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Author

Summary, in English

In consecutive series of 326 laryngeal cancer patients, of 29 (9%) with stage T3N0 glottic carcinomas, 23 achieved complete local remission after curative radiotherapy and form the basis of the present investigation. Flow cytometry determinations of DNA-ploidy status and the S-phase fraction, and a "histopathological malignancy grading system" were evaluated as possible patient- and/or tumor-related predictors of local recurrence. Twelve patients (52%) were continuously disease-free after radiotherapy, whereas 10 (43%) manifested local recurrence, and one distant metastasis. The radiotherapy delivered to patients who later suffered from a local recurrence did not differ from those being continuously disease-free. The frequency of local recurrence was significantly correlated to patients whose primary tumours manifested a low S-phase fraction (p < 0.05). A low S-phase fraction may indicate slowly proliferating tumour-cells, which become more radioresistant on exposure to a series of fractionated doses, as their reassortment into sensitive phases will be proportionately slower.

Publishing year

1993

Language

English

Pages

220-224

Publication/Series

Acta Oto-Laryngologica

Volume

113

Issue

1

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Otorhinolaryngology

Keywords

  • laryngeal carcinoma
  • recurrence
  • proliferation
  • flow cytometry
  • hisroparhological grading system

Status

Published

ISBN/ISSN/Other

  • ISSN: 1651-2251