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Amperometric In Vitro Monitoring of Penetration through Skin Membrane

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Author

  • Hala Gari
  • Jadwiga Rembiesa
  • Ignas Masilionis
  • Naida Vreva
  • Birgitta Svensson
  • Torbjorn Sund
  • Henri Hansson
  • Anna Karin Moren
  • Malin Sjöö
  • Marie Wahlgren
  • Johan Engblom
  • Tautgirdas Ruzgas
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Summary, in English

The aim of this study was to demonstrate that penetration of quercetin, hydrogen peroxide and ascorbic acid through skin membranes can be monitored amperometrically. Skin membrane was fixed on the top of chemically modified electrodes and penetration of the appropriate compound was registered as electrode current. The methodology allows the study of penetration from solution as well as from pharmaceutical creams. From real-time measurements of electrode current, fluxes and diffusion coefficients of mentioned compounds in skin membranes have been estimated.

Department/s

Publishing year

2015

Language

English

Pages

111-117

Publication/Series

Electroanalysis

Volume

27

Issue

1

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Cancer and Oncology

Keywords

  • Penetration
  • Transdermal delivery
  • Amperometry
  • Quercetin
  • Hydrogen
  • peroxide
  • Ascorbic acid
  • Skin membrane

Status

Published

Research group

  • Cell Pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 1040-0397