Association between urinary N-acetyl-beta-glucosaminidase and its isoenzyme patterns and microangiopathy in type 1 diabetes mellitus

Summary, in English

Urinary N-acetyl-beta-glucosaminidase (NAG) and its isoenzymes (NAG A and NAG B) in samples from 87 type 1 diabetic patients and 40 apparently healthy reference subjects were studied with enzyme immunoassays. The diabetic patients had higher concentrations of urinary NAG than did the control subjects (P less than 0.01), but the isoenzyme pattern did not differ. There was a positive correlation between metabolic control (Hb A1c concentrations) and total NAG (P less than 0.01), NAG A (P less than 0.01), and NAG B (P less than 0.001). The diabetic patients were divided into three groups, depending on the degree of retinopathy. Subjects with severe forms of retinopathy did not have increased concentrations of urinary NAG unless they had concomitant nephropathy. The isoenzyme pattern was similar irrespective of degree of retinopathy or nephropathy. The results indicate that concentrations of urinary NAG are positively correlated to the degree of nephropathy, whereas there is no such correlation to the degree of retinopathy.

• Author: Carl-David Agardh; Elisabet Agardh; Anders Isaksson; Björn Hultberg
• Department/s: Department of Clinical Sciences, Malmö; Division of Clinical Chemistry and Pharmacology
• Publishing year: 1991
• Language: English
• Pages: 1696-1699
• Publication/Series: Clinical Chemistry
• Volume: 37
• Issue: 10 Pt 1
• Links: http://www.clinchem.org/cgi/reprint/37/10/1696
• Document type: Journal article
• Publisher: American Association for Clinical Chemistry
• Topic: Biochemistry and Molecular Biology
• Status: Published
• ISBN/ISSN/Other: ISSN: 0009-9147