HCV-RNA levels increase during pregnancy in women with chronic hepatitis C
Author
Summary, in English
Alanine aminotransferase (ALT) levels decline during pregnancy in women chronically infected with hepatitis C virus (HCV). In order to understand further the underlying mechanisms, we prospectively followed 10 chronically infected women before, during and after pregnancy. ALT levels were analysed together with quantification of serum HCV-RNA using the branched DNA technology. As anticipated, the ALT levels significantly declined late in pregnancy and increased again after delivery. HCV-RNA levels, conversely, significantly increased late in pregnancy and returned to baseline levels 1 y after delivery. These findings suggest the importance of immune mediated mechanisms in controlling the viral replication and contributing to the liver injury in chronic hepatitis C.
Department/s
Publishing year
1998
Language
English
Pages
111-113
Publication/Series
Scandinavian Journal of Infectious Diseases
Volume
30
Issue
2
Document type
Journal article
Publisher
Informa Healthcare
Topic
- Infectious Medicine
Status
Published
Research group
- Clinical Microbiology, Malmö
ISBN/ISSN/Other
- ISSN: 1651-1980