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Antioxidant Effects of Secondary Metabolites from Geranium psilostemon

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Author

  • Didem Sohretoglu
  • Suna Atasayar Sabuncuoglu
  • M. Koray Sakar
  • Hilal Ozgunes
  • Olov Sterner

Summary, in English

An investigation was made of the effects on endogenous antioxidant enzyme activities and H2O2-induced lipid peroxidation inhibition in human red blood cells of the crude MeOH extract and its EtOAc, n-BuOH, and H2O sub-extracts obtained from aerial parts of Geranium psilostemon Ledeb., as well as compounds isolated from the most active EtOAc extract. Gallic acid (1), methyl gallate (2), pusilagin (3), 1,3,6-tri-O-galloyl-beta-glucopyranoside (4), 1,2,3,4,6-penta-O-galloyl-beta-glucopyranoside (5), kaempferol (6), quercetin (7), kaempferol 7-O-alpha-rhamnopyranoside (8), and quercetin 7-O-alpha-rhamnopyranoside (9) were isolated from the aerial parts of the title plant, and their structures identified from spectroscopic (UV, 1D- and 2D- NMR) and spectrometric (TOF-MS) data. All extracts and isolated compounds inhibited H2O2-induced lipid peroxidation and also enhanced the activity of superoxide dismutase (SOD) and catalase (CAT).

Publishing year

2010

Language

English

Pages

899-902

Publication/Series

Natural Product Communications

Volume

5

Issue

6

Document type

Journal article

Publisher

Natural Products Inc

Topic

  • Organic Chemistry

Keywords

  • pentagalloyl glucose
  • trigalloyl glucose
  • SOD
  • CAT
  • antioxidant
  • Geranium
  • Geraniaceae

Status

Published

ISBN/ISSN/Other

  • ISSN: 1934-578X