Circulating complexes between tumour necrosis factor-alpha and etanercept predict long-term efficacy of etanercept in juvenile idiopathic arthritis.

Summary, in English

The relationship between tumour necrosis factor-alpha (TNF-α) and drug survival had not been studied in juvenile idiopathic arthritis (JIA) and there were no laboratory tests to predict the long-term efficacy of biological drugs for JIA. We studied if serum levels of TNF-α, free or bound to etanercept, could predict long-term efficacy of etanercept in children with JIA.

• Author: Robin Kahn; Elisabet Berthold; Birgitta Gullstrand; Tobias Schmidt; Fredrik Kahn; Pierre Geborek; Tore Saxne; Anders Bengtsson; Bengt Månsson
• Department/s: Paediatrics (Lund); Rheumatology; Division of Microbiology, Immunology and Glycobiology - MIG; Infection Medicine (BMC); EpiHealth: Epidemiology for Health
• Publishing year: 2016
• Language: English
• Pages: 427-432
• Publication/Series: Acta paediatrica
• Volume: 105
• Issue: 4
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26707699?dopt=Abstract; http://dx.doi.org/10.1111/apa.13319
• Document type: Journal article
• Publisher: Wiley-Blackwell
• Topic: Rheumatology and Autoimmunity; Pediatrics
• Status: Published
• ISBN/ISSN/Other: ISSN: 1651-2227