The role of cystatin C in cerebral amyloid angiopathy and stroke: Cell biology and animal models : cell biology and animal models
Author
Summary, in English
A variant of the cysteine protease inhibitor, cystatin C, forms amyloid deposited in the cerebral vasculature of patients with hereditary cerebral hemorrhage with amyloidosis, Icelandic type (HCHWA-I), leading to cerebral hemorrhages early in life. However, cystatin C is also implicated in neuronal degenerative diseases in which it does not form the amyloid protein, such as Alzheimer disease (AD). Accumulating data suggest involvement of cystatin C in the pathogenic processes leading to amyloid deposition in cerebral vasculature and most significantly to cerebral hemorrhage in patients with cerebral amyloid angiopathy (CAA). This review focuses on cell culture and animal models used to study the role of cystatin C in these processes.
Department/s
Publishing year
2006-01
Language
English
Pages
60-70
Publication/Series
Brain Pathology
Volume
16
Issue
1
Links
Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Medicinal Chemistry
- Pharmacology and Toxicology
Keywords
- Alzheimer Disease
- Animals
- Cerebral Amyloid Angiopathy
- Cystatin C
- Cystatins
- Disease Models, Animal
- Humans
- Neurofibrils
- Stroke
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Review
Status
Published
ISBN/ISSN/Other
- ISSN: 1750-3639