Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production.

Summary, in English

The steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/pro-inflammatory attacks. Low serum levels of vitamin D3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple transcriptional targets within the inflammatory system.

• Author: Daniel Svensson; Daniel Nebel; Bengt-Olof Nilsson
• Department/s: Vascular Physiology
• Publishing year: 2016
• Language: English
• Pages: 25-32
• Publication/Series: Inflammation Research
• Volume: 65
• Issue: 1
• Full text: - 394 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26433491?dopt=Abstract; http://dx.doi.org/10.1007/s00011-015-0884-z
• Document type: Journal article review
• Publisher: Birkhäuser Verlag
• Topic: Immunology in the medical area
• Status: Published
• Project: Vitamin D and estrogen receptor signaling
• Research group: Vascular Physiology
• ISBN/ISSN/Other: ISSN: 1420-908X