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Surveillance of Vaccine Safety: Comparison of parental reports with routine surveillance and a clinical trial

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Author

Summary, in English

One way to maintain confidence in vaccination programmes is to improve monitoring of immunisation safety. We studied active parental reporting of adverse events after a booster dose of diphtheria-tetanus toxoid (DT). 7193 children received the vaccine. Questionnaires were submitted by 84.2% of the parents, who reported reactions for 9.2% of the children. Four percent of events were classified as moderate/severe by interviews. Relative risk of redness and swelling reported was 0.24 (95% CI. 0.13-0.42) compared to a clinical trial, while it was 71.0 (44-114) compared to passive surveillance. Active surveillance by parental reports is a useful complement to passive surveillance of childhood immunisations to generate hypotheses for evaluation in controlled studies. (C) 2009 Elsevier Ltd. All rights reserved.

Publishing year

2009

Language

English

Pages

2042-2047

Publication/Series

Vaccine

Volume

27

Issue

14

Document type

Journal article

Publisher

Elsevier

Topic

  • Nursing
  • Public Health, Global Health, Social Medicine and Epidemiology

Keywords

  • Local reactions
  • Vaccine safety
  • Parental reports

Status

Published

Research group

  • Family Medicine and Community Medicine

ISBN/ISSN/Other

  • ISSN: 1873-2518