Persistence and evolution of allergen-specific IgE repertoires during subcutaneous specific immunotherapy.

Summary, in English

Specific immunotherapy (SIT) is the only treatment with proved long-term curative potential in patients with allergic disease. Allergen-specific IgE is the causative agent of allergic disease, and antibodies contribute to SIT, but the effects of SIT on aeroallergen-specific B-cell repertoires are not well understood.

• Author: Mattias Levin; Jasmine J King; Jacob Glanville; Katherine J L Jackson; Timothy J Looney; Ramona A Hoh; Adriano Mari; Morgan Andersson; Lennart Greiff; Andrew Z Fire; Scott D Boyd; Mats Ohlin
• Department/s: Department of Immunotechnology; Otorhinolaryngology (Lund)
• Publishing year: 2016
• Language: English
• Pages: 1535-1544
• Publication/Series: The Journal of Allergy and Clinical Immunology
• Volume: 137
• Issue: 5
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26559321?dopt=Abstract; http://dx.doi.org/10.1016/j.jaci.2015.09.027
• Document type: Journal article
• Publisher: Elsevier
• Topic: Respiratory Medicine and Allergy
• Status: Published
• ISBN/ISSN/Other: ISSN: 1097-6825