High disaccharide intake associates with atherogenic lipoprotein profile.
Author
Summary, in English
Increased plasma concentrations of small LDL particles denote an atherogenic lipoprotein phenotype (ALP) that is correlated with increased circulating TAG and reduced HDL-cholesterol. Principal component analyses of subfraction concentrations have previously been used in the Swedish population-based Malmö Diet and Cancer (MDC) cohort to identify three independent components, one pattern representing the ALP. The aim of the present study was to examine the associations between macronutrient intakes and the principal component representing the ALP. We examined 4301 healthy subjects (46-68 years old, 60 % women) at baseline in the MDC cohort. Dietary data were collected using a modified diet history method. Plasma lipoprotein subfractions were measured using a high-resolution ion mobility method. The principal component corresponding to the ALP was significantly associated with a higher intake of disaccharides, and inversely related to protein and alcohol consumption (P < 0·001 for all). The present findings indicate that the ALP may be improved by a low intake of disaccharides, and moderate intakes of protein and alcohol.
Department/s
Publishing year
2012
Language
English
Pages
1062-1069
Publication/Series
British Journal of Nutrition
Volume
107
Links
Document type
Journal article
Publisher
Cambridge University Press
Topic
- Nutrition and Dietetics
Status
Published
Research group
- Nutrition Epidemiology
- Diabetes - Cardiovascular Disease
- Cardiovascular Research - Immunity and Atherosclerosis
- Cardiovascular Research - Epidemiology
ISBN/ISSN/Other
- ISSN: 1475-2662