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Hyperhomocysteinemia and changed plasma thiol redox status in chronic obstructive pulmonary disease

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Author

Summary, in English

Reduced and total homocysteine, cysteine, glutathione and cysteinylglycine in plasma were investigated in 19 patients with chronic obstructive pulmonary disease and in 29 healthy subjects. The purpose was to examine the influence of pro-oxidant activity caused by the lung disease on the metabolism of homocysteine and other plasma thiols. We observed a decreased concentration of reduced glutathione and a decreased ratio of reduced/total glutathione in the patients compared to the healthy individuals, which supports the hypothesis of an association between free radicals and pathogenesis in some lung diseases. We also observed an increased total plasma homocysteine. The influence of a possible extracellular pro-oxidant activity on the concentration of total plasma homocysteine is discussed.

Publishing year

2001

Language

English

Pages

229-233

Publication/Series

Clinical Chemistry and Laboratory Medicine

Volume

39

Issue

3

Document type

Journal article

Publisher

De Gruyter

Topic

  • Clinical Laboratory Medicine

Status

Published

ISBN/ISSN/Other

  • ISSN: 1434-6621