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A variant in FTO shows association with melanoma risk not due to BMI

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Author

  • Mark M. Iles
  • Matthew H. Law
  • Simon N. Stacey
  • Jiali Han
  • Shenying Fang
  • Ruth Pfeiffer
  • Mark Harland
  • Stuart MacGregor
  • John C. Taylor
  • Katja K. Aben
  • Lars A. Akslen
  • Marie-Francoise Avril
  • Esther Azizi
  • Bert Bakker
  • Kristrun R. Benediktsdottir
  • Wilma Bergman
  • Giovanna Bianchi Scarra
  • Kevin M. Brown
  • Donato Calista
  • Valerie Chaudru
  • Maria Concetta Fargnoli
  • Anne E. Cust
  • Florence Demenais
  • Anne C. de Waal
  • Tadeusz Debniak
  • David E. Elder
  • Eitan Friedman
  • Pilar Galan
  • Paola Ghiorzo
  • Elizabeth M. Gillanders
  • Alisa M. Goldstein
  • Nelleke A. Gruis
  • Johan Hansson
  • Per Helsing
  • Marko Hocevar
  • Veronica Hoiom
  • John L. Hopper
  • Christian Ingvar
  • Marjolein Janssen
  • Mark A. Jenkins
  • Peter A. Kanetsky
  • Lambertus A. Kiemeney
  • Julie Lang
  • G. Mark Lathrop
  • Sancy Leachman
  • Jeffrey E. Lee
  • Jan Lubinski
  • Rona M. Mackie
  • Graham J. Mann
  • Nicholas G. Martin
  • Jose I. Mayordomo
  • Anders Molven
  • Suzanne Mulder
  • Eduardo Nagore
  • Srdjan Novakovic
  • Ichiro Okamoto
  • Jon H. Olafsson
  • Håkan Olsson
  • Hubert Pehamberger
  • Ketty Peris
  • Maria Pilar Grasa
  • Dolores Planelles
  • Susana Puig
  • Joan Anton Puig-Butille
  • Juliette Randerson-Moor
  • Celia Requena
  • Licia Rivoltini
  • Monica Rodolfo
  • Mario Santinami
  • Bardur Sigurgeirsson
  • Helen Snowden
  • Fengju Song
  • Patrick Sulem
  • Kristin Thorisdottir
  • Rainer Tuominen
  • Patricia Van Belle
  • Nienke van der Stoep
  • Michelle M. van Rossum
  • Qingyi Wei
  • Judith Wendt
  • Diana Zelenika
  • Mingfeng Zhang
  • Maria Teresa Landi
  • Gudrnar Thorleifsson
  • D. Timothy Bishop
  • Christopher I. Amos
  • Nicholas K. Hayward
  • Kari Stefansson
  • Julia A. Newton Bishop
  • Jennifer H. Barrett
Show all

Summary, in English

We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 x 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanomasusceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.

Department/s

Publishing year

2013

Language

English

Pages

428-432

Publication/Series

Nature Genetics

Volume

45

Issue

4

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Surgery
  • Cancer and Oncology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1546-1718