Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety
Author
Summary, in English
Modification of the St. John's wort acylphloroglucinol constituent, hyperforin (1), by acylation, alkylation, and oxidation resulted in detrimental effects on the inhibition of the synaptosomal accumulation of serotonin, showing the existence of definite structure-activity relationships in this in vitro test system and highlighting the role of the enolized cyclohexanedione moiety for activity on neurotransmitter reuptake.
Department/s
Publishing year
2002
Language
English
Pages
433-438
Publication/Series
Journal of Natural Products
Volume
65
Issue
4
Document type
Journal article
Publisher
The American Chemical Society (ACS)
Topic
- Organic Chemistry
Status
Published
ISBN/ISSN/Other
- ISSN: 0163-3864