DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets.

Summary, in English

Insulin secretion is enhanced upon the binding of Glucagon-like peptide-1 (GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats has been established, it is still unknown if this is caused by differential DNA methylation of GLP1R in pancreatic islets of type 2 diabetic patients.

• Author: Elin Hall; Tasnim Dayeh; Clare L Kirkpatrick; Claes Wollheim; Marloes Dekker Nitert; Charlotte Ling
• Department/s: Translational Muscle Research; Diabetes - Epigenetics; EXODIAB: Excellence of Diabetes Research in Sweden
• Publishing year: 2013
• Language: English
• Publication/Series: BMC Medical Genetics
• Volume: 14
• Issue: Jul,23
• Full text: - 683 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/23879380?dopt=Abstract; http://dx.doi.org/10.1186/1471-2350-14-76
• Document type: Journal article
• Publisher: BioMed Central (BMC)
• Topic: Medical Genetics
• Status: Published
• Research group: Translational Muscle Research; Diabetes - Epigenetics
• ISBN/ISSN/Other: ISSN: 1471-2350