Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: Possible interaction with genes involved in 20-HETE and EETs metabolism.
Author
Summary, in English
A high intake of omega-3 polyunsaturated fatty acids (ω-3 PUFAs), has been associated with reduced levels of blood pressure (BP). Their antihypertensive action may be due to the reduction of the ω-6/ω-3 ratio and the resulting competitive effect of ω-3 as compared to arachidonic acid (an ω-6 PUFA) as a substrate of cytochrome P450 (CYP450) enzymes involved in the production of vasoactive mediators. Some functional polymorphisms (SNPs), in genes which encode for the same enzymes, were associated with hypertension and ischemic stroke in the Malmö Diet and Cancer (MDC), a Swedish urban-based longitudinal study. The aim of this study was to evaluate the effect of the intake of different types of PUFAs on BP change over time (Δ-BP; mean follow-up 16.6±1.5 years; n=3.550 with complete phenotypic data), also considering the interaction with SNPs in genes involved in their metabolism via CYP450.
Department/s
Publishing year
2015
Language
English
Pages
126-133
Publication/Series
Prostaglandins & other Lipid Mediators
Volume
120
Issue
May 16
Links
Document type
Journal article
Publisher
Elsevier
Topic
- Endocrinology and Diabetes
- Cardiac and Cardiovascular Systems
Status
Published
Research group
- Diabetes - Cardiovascular Disease
- Genomics, Diabetes and Endocrinology
- Internal Medicine - Epidemiology
- Cardiovascular Research - Epidemiology
- Cardiovascular Research - Hypertension
ISBN/ISSN/Other
- ISSN: 1098-8823