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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

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Author

  • Richa Saxena
  • Benjamin F. Voight
  • Valeriya Lyssenko
  • Noel P. Burtt
  • Paul I. W. de Bakker
  • Hong Chen
  • Jeffrey J. Roix
  • Sekar Kathiresan
  • Joel N. Hirschhorn
  • Mark J. Daly
  • Thomas E. Hughes
  • Leif Groop
  • David Altshuler
  • Peter Almgren
  • Jose C. Florez
  • Joanne Meyer
  • Kristin Ardlie
  • Kristina Bengtsson Boström
  • Bo Isomaa
  • Guillaume Lettre
  • Ulf Lindblad
  • Helen N. Lyon
  • Olle Melander
  • Christopher Newton-Cheh
  • Peter Nilsson
  • Marju Orho-Melander
  • Lennart Råstam
  • Elizabeth K. Speliotes
  • Marja-Riitta Taskinen
  • Tiinamaija Tuomi
  • Candace Guiducci
  • Anna Berglund
  • Joyce Carlson
  • Lauren Gianniny
  • Rachel Hackett
  • Liselotte Hall
  • Johan Holmkvist
  • Esa Laurila
  • Marketa Sjögren
  • Maria Sterner
  • Aarti Surti
  • Margareta Svensson
  • Malin Svensson
  • Ryan Tewhey
  • Brendan Blumenstiel
  • Melissa Parkin
  • Matthew DeFelice
  • Rachel Barry
  • Wendy Brodeur
  • Jody Camarata
  • Nancy Chia
  • Mary Fava
  • John Gibbons
  • Bob Handsaker
  • Claire Healy
  • Kieu Nguyen
  • Casey Gates
  • Carrie Sougnez
  • Diane Gage
  • Marcia Nizzari
  • Stacey B. Gabriel
  • Gung-Wei Chirn
  • Qicheng Ma
  • Hemang Parikh
  • Delwood Richardson
  • Darrell Ricke
  • Shaun Purcell
Show all

Summary, in English

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.

Publishing year

2007

Language

English

Pages

1331-1336

Publication/Series

Science

Volume

316

Issue

5829

Document type

Journal article

Publisher

American Association for the Advancement of Science (AAAS)

Topic

  • Other Clinical Medicine
  • Public Health, Global Health, Social Medicine and Epidemiology
  • Medicinal Chemistry
  • Endocrinology and Diabetes

Status

Published

Research group

  • Translational Muscle Research
  • Community Medicine
  • Cardiovascular Research - Hypertension
  • Internal Medicine - Epidemiology
  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1095-9203