Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.

Summary, in English

In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK, and evaluate its predictive value for the development of breast cancer in a large population of middle-aged women and an independent study population.

• Author: Olle Melander; Marju Orho-Melander; Jonas Manjer; Thomas Svensson; Peter Almgren; Peter Nilsson; Gunnar Engström; Bo Hedblad; Signe Borgquist; Oliver Hartmann; Joachim Struck; Andreas Bergmann; Mattias Belting
• Department/s: Tumor microenvironment; EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health; Cardiovascular Research - Hypertension; Diabetes - Cardiovascular Disease; Surgery; Translational Muscle Research; Internal Medicine - Epidemiology; Cardiovascular Research - Epidemiology; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Breastcancer-genetics; Tumor microenvironment
• Publishing year: 2015
• Language: English
• Pages: 81-2632
• Publication/Series: Journal of Clinical Oncology
• Volume: 33
• Issue: 24
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26169618?dopt=Abstract; http://dx.doi.org/10.1200/JCO.2014.59.7682
• Document type: Journal article
• Publisher: American Society of Clinical Oncology
• Topic: Cancer and Oncology
• Status: Published
• Research group: Tumor microenvironment; Cardiovascular Research - Hypertension; Diabetes - Cardiovascular Disease; Surgery; Genomics, Diabetes and Endocrinology; Internal Medicine - Epidemiology; Cardiovascular Research - Epidemiology
• ISBN/ISSN/Other: ISSN: 1527-7755